The doctors who worked with the researchers evaluated 22 of the participants, all between 2 and 5 years of age, and documented improvements in 13 of them six months after a single infusion. Supporters of stem cell therapy for autism say it can reduce characteristics of autism. They say it can improve behavior, anxiety, social skills, communication, speech, and ability to concentrate.
stem cell therapyis rapidly evolving as a potential treatment for many diseases, such as autism, that do not have any medical or surgical treatment available.
Selective areas in the brain of people with autism have been observed to be damaged and not functioning normally. The main goal of this therapy is to reverse this damage by replacing damaged cells with healthy cells. As a result, it restores lost functions and helps to improve the quality of life. This therapy makes individuals independent and helps them to integrate into society.
In most cases, you won't feel an improvement for about three weeks, and in some cases, six to eight weeks. However, once improvement begins, you may notice changes in your body for six months or more. Beyond stem cell therapy as a valuable tool for treating autism, stem cells also offer the possibility of an in-depth study of the pathology of ASD. Children of immunoactivated mothers (autism model of maternal immune activation) develop preferential myeloid lineage potential and altered differentiation of HSCs, 86 The importance of this work reflects that immune changes during maternal life could confer alterations in the stem cell lineage throughout of all the life of the offspring.
Another clinical trial indicates that stem cell therapy works best when combined with an educational intervention. The study shows that the combined results of both have significantly helped children with autism improve their verbal, communication and day-to-day social skills. Interestingly, combination therapy has also been shown to reduce hyperactivity and repetitive behaviors. Researchers have also compared these changes to natural childhood development and hope that stem cell therapy has the potential to become a standard treatment option for children with autism.
Stem cells are cells in the body that have the ability to multiply and differentiate into specialized cells. Treatment involves intravenous infusions of umbilical cord blood (MNC) mononuclear cells, a component of blood that includes stem cells. The U.S. FDA does not approve any stem cell product from any source, including the patient himself, to treat autism or any other common condition or disease.
In vitro, iPSCs can be made to differentiate into several cell types such as dopamine and motor neurons, dendritic cells, functional cardiomyocytes, macrophages, hepatocytes, and hematopoietic and endothelial cells. In summary, it usually takes at least a month before you begin to notice the gradual effects of stem cell therapy, and you may notice changes in your medical condition for 6 months or more. This means that, when used in some medical treatments, stem cells have the potential to solve many underlying problems. The FDA has approved the limited use of stem cells in treatments for some types of cancer or disorders of the blood and bone marrow.
The group received a bone marrow-derived mononuclear cell transplant (BMMNC), which uses stem cells from the blood. The purpose of this review is to consider the status of these clinical trials of cell therapies for autism, to assess progress, to ask if it justifies the continuation of this approach and, if so, what steps should be taken by clinical and preclinical researchers alike to improve the prospects of success. Initially, the first theory about the mechanism of action of stem cells was that cell therapy could act through a “cell replacement mechanism”; today, large emerging evidence has shown that cell therapy works by providing trophic or “chaperone” support to injured tissue and brain. Three other major stem cell studies have been conducted in children with autism, but all have had wide variation in the treatments used, the study participants, the way the results were measured, and even the way the studies were designed.
One important difference is that children with metabolic disorders received chemotherapy before cord blood transplantation and stem cells were engrafted for life, while in the treatment of neurodevelopmental disorders, children do not receive chemotherapy and stem cells are not expected to engraft. There is some anecdotal evidence that clinics offering unapproved stem cell treatments benefit people with autism; however, there is very little evidence from medical studies that this is possible. These changes correlate with clinical improvements confirming the positive effect of stem cell therapy on autism. .